My name is Huang San (a pseudonym), a 76-year-old Shanghainese man who has smoked for more than 50 years. I was diagnosed with small-cell lung cancer at the age of 75, and then not long afterwards it was discovered that small-cell lung cancer had metastasized to my brain, which was really too hard for me to bear. Fortunately, the doctor said that there was a new drug effective for this disease, called imfinzi. I was given imfinzi once per month in combination with alimta and lubei. Since it was a new drug, I was full of expectation and thought that this tumor would improve.

However, my condition did not improve after 3 months of treatment. My breathing was getting more and more difficult, and I coughed a lot, feeling that my heart and liver were going to be coughed out. I worried again and really regretted that I had smoked too much, one pack a day, since I was young and did not quit even when my daughter told me to do so. I didn't want to struggle too much in my age and thought that I could live as long as I could. But the pain was terrible and I wanted to make my granddaughter a ponytail and take her to the park in a princess dress again, so my daughter asked the doctor if there was anything else we could do.

My blood was taken and sent together with previous tissue slides for tumor gene detection by YuceBio to detect something like neoantigen. If the testing results were acceptable, I may get personalized tumor vaccine. The test results at the time indicated that 8 out of 12 had responded.

It didn't take long for the personalized tumor vaccine to arrive and I had 4 shots in a row. After a while, my breathing was smoother and I had less of a pain and no more cough during the night.

I went back for the follow-up examination this year after the pandemic had passed and the doctor said that the tumor in my brain had not grown any more and had not metastasized.

It was really great!